1/16/2011 4:57:13 PM
tedpath
Posts: 1
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I am new to this site. To respond to your query, this site states 43% of clear cell renal ca is positive for AMACR, though the figure may be close to yours, based on one of the 4 references, the LIN et al study which reported 68% of 70 clear cell tumors. two of the others, showed 25% in both (and usually weak or focal) and the 4th reference focused on a small number of papillary renal carcinomas with clear cell change. there are perhaps other studies with large enough numbers that have not been included here. these differences likely relate to differences in technique and/or clone used, definitions of what constitutes positive cutoffs in each, and perhaps classification of a subset of tumors based on H and E alone. Most reviews I have seen in IHC in renal tumors do not give specific numbers or percentages for each marker and tumor type and many state that clear cell RCC is negative for AMACR which is not the case. these are of course issues that permeate through much of iHC studies reported and highlight the need for a good panel of appropriate markers for most differential diagnoses. I do not have a large enough database studies at my institution. Mahul Amin may be amongst the best experts in this area. I might be able to look up his talk from the IHC course a few years ago and get back to you with more specifics. My work e-mail is richard.eisen@greenwichhospital.org if you wish to follow up.
Regards, R. Eisen
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