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<title>Pathpedia.com - Recent Posts</title>
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<description>Pathpedia.com - Recent Posts</description>
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<pubDate>Mon, 12 Jul 2010 23:27:29 GMT</pubDate>
<lastBuildDate>Mon, 12 Jul 2010 23:27:29 GMT</lastBuildDate>
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<link>http://www.pathpedia.com/Forum/topic8-diagnosis-of-mds-with-subtle-dysplastic-changes.aspx</link>
<title>Topic &quot;Diagnosis of MDS with subtle dysplastic changes?&quot; a message from Kaleem</title>
<description><![CDATA[The diagnosis of MDS in the absence of significant dysplasia is often challenging. The clinicians are not happy with a descriptive diagnosis because such a diagnosis does not provide any meaningful answer to their question. But at the same time there are limitations to which a pathologist can make a definitive diagnosis. This difficulty happens most often in cases of refractory anemia and not other categories. If I find more than "occasional" red cell precursors with "real" dysplastic changes I make the diagnosis of refractory anemia on morphologic grounds in an appropriate clinical context and supporting lab findings. Most of the times cytogenetics comes back clonal.]]></description>
<pubDate>Mon, 12 Jul 2010 23:27:29 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic8-diagnosis-of-mds-with-subtle-dysplastic-changes.aspx</link>
<title>Topic &quot;Diagnosis of MDS with subtle dysplastic changes?&quot; a message from Hanif</title>
<description><![CDATA[<b>D_Novak</b> wrote:<br/><div class=quote>We get quite a few bone marrow biopsies done at our hospital for unexplained cytopenia. Obvious dysplasia is seen in a few cases and in which I am comfortable calling it myelodysplasia. But in some cases the dysplasia is minimal and I don’t make the calls but clinicians strongly suspect MDS. Almost all of those cases have normal cytogenetics. Sometimes, we repeat the bone marrow biopsy for development of overt dysplasia. My question is can we call involvement by refractory anemia with only mild dyserythropoiesis and normal cytogenetics?</div> <br/><br/>My threshold for MDS diagnosis is a little bit high.  I donot diagnose MDS just on pancytopenia and mild dysplasia.  There are diagnostic criteria in WHO.  With no cytogenetic abnormality, I diagnose as "Hypocellular/Hypercellular bone marrow with erythroid or myeloid dysplasia".<br/><br/>Hanif]]></description>
<pubDate>Mon, 12 Jul 2010 12:42:04 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic8-diagnosis-of-mds-with-subtle-dysplastic-changes.aspx</link>
<title>Topic &quot;Diagnosis of MDS with subtle dysplastic changes?&quot; a message from D_Novak</title>
<description><![CDATA[We get quite a few bone marrow biopsies done at our hospital for unexplained cytopenia. Obvious dysplasia is seen in a few cases and in which I am comfortable calling it myelodysplasia. But in some cases the dysplasia is minimal and I don’t make the calls but clinicians strongly suspect MDS. Almost all of those cases have normal cytogenetics. Sometimes, we repeat the bone marrow biopsy for development of overt dysplasia. My question is can we call involvement by refractory anemia with only mild dyserythropoiesis and normal cytogenetics?]]></description>
<pubDate>Mon, 12 Jul 2010 09:06:27 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic7-salaries-for-fresh-graduates.aspx</link>
<title>Topic &quot;Salaries for fresh graduates&quot; a message from Buddy</title>
<description><![CDATA[Your prospects look good. You can expect a starting salary of $200,000 to $250,000 depending on the group and their dire need for you. It may a little higher or little lower than that but I would be looking in that range. Good luck.]]></description>
<pubDate>Wed, 23 Jun 2010 10:08:00 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic7-salaries-for-fresh-graduates.aspx</link>
<title>Topic &quot;Salaries for fresh graduates&quot; a message from Buddy</title>
<description><![CDATA[Dear Zoe:<br/>Your fellows told you the right thing that salaries can range widely depending on a variety of factors including but not limited to your training (AP only vs CP only vs AP/CP), kind of fellowship, geography (I presume you are in U.S.A), practice setting (University, Private practice, Commercial lab), and the list goes on and on. It can range from US $60,000 to $250,000 depending on where you are going to. Without knowing your exact situation, credentials, and preferences I could not make a good guess on how much you should expect. Give me more details about your situation.]]></description>
<pubDate>Tue, 15 Jun 2010 12:21:47 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic6-colon-polyps-hg-dysplasia-v-cis-v-intramucosal-ca.aspx</link>
<title>Topic &quot;colon polyps, HG dysplasia v CIS v intramucosal Ca&quot; a message from Johnny</title>
<description><![CDATA[No, I don't think there is any movement to use the terms "Intramucosal carcinoma" or "CIS" for what we know and call "High-grade dysplasia." This terminology is not new to the 7th edition and is listed also in the 6th edition. It is confusing to a lot of pathologists who follow the AJCC manual for staging and see this terminology. The term "Intramucosal carcinoma" and "CIS" may be more appropriate for lesions with invasion through the basement membranes but limited to the mucosa whereas the term "High-grade dysplasia" may be more applicable with complex lesions without any invasion of the basement membrane. As long as the terms are communicated well with clinicians and used consistently for the same lesions it is OK to use either. You are not alone in this quandary.]]></description>
<pubDate>Sun, 23 May 2010 17:00:42 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic6-colon-polyps-hg-dysplasia-v-cis-v-intramucosal-ca.aspx</link>
<title>Topic &quot;colon polyps, HG dysplasia v CIS v intramucosal Ca&quot; a message from 64992C36-0BC0-4DEB-B2E0-5481359879D9</title>
<description><![CDATA[Seventh ed AJCC staging manual uses term intramucosal carcinoma and CIS for colon polyps with what I feel we had been told should termed as High Grade dysplasia.  Basically cribriform architecture, confluent growth and even infiltration confined to lamina propria (no breech of muscularis mucosa, or involvement of submucosa thus no lymphatics) was best classified as high grade dysplasia rather than the use of term "carcinoma".  Is there a movement back toward CIS terminology?]]></description>
<pubDate>Tue, 18 May 2010 09:31:09 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic4-acute-leukemias-of-ambiguous-lineage.aspx</link>
<title>Topic &quot;Acute leukemias of ambiguous lineage.&quot; a message from Buddy</title>
<description><![CDATA[The given immunoprofile is most consistent with acute bi-phenotypic leukemia which is treated with an AML protocol.]]></description>
<pubDate>Wed, 09 Dec 2009 11:41:26 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic4-acute-leukemias-of-ambiguous-lineage.aspx</link>
<title>Topic &quot;Acute leukemias of ambiguous lineage.&quot; a message from Hanif</title>
<description><![CDATA[I have a case of acute leukemia. The blast gate is CD45 dim to negative. The blast cells express CD34, CD13, CD33, CD19, CD10, HLA-DR, nTdT, and cMPO.  Any idea or suggestion?<br/>edited by MuhammadPathan on 12/8/2009<br/>edited by MuhammadPathan on 12/8/2009<br/><em>edited by Buddy on 12/9/2009</em>]]></description>
<pubDate>Tue, 08 Dec 2009 21:44:12 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic3-amacr-staining.aspx</link>
<title>Topic &quot;AMACR staining&quot; a message from Buddy</title>
<description><![CDATA[Although AMACR staining has been reported to be less frequent in clear cell renal cell carcinoma we have seen more than 50% of our cases of clear cell RCC to be positive. May be it is common in this type of RCC. What has been the experience of other people?]]></description>
<pubDate>Sun, 06 Dec 2009 21:56:53 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic2-pathology-20.aspx</link>
<title>Topic &quot;Pathology 2.0&quot; a message from zshaz</title>
<description><![CDATA[I think we need more people to get engaged in thinking and promote the idea of pathology 2.0. The uses are abound and would facilitate international dialogue.]]></description>
<pubDate>Sun, 06 Dec 2009 13:16:16 GMT</pubDate>
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<link>http://www.pathpedia.com/Forum/topic2-pathology-20.aspx</link>
<title>Topic &quot;Pathology 2.0&quot; a message from Buddy</title>
<description><![CDATA[<span style="color:rgb(15,37,63)">I read with interest the articles in AJCP by Schreiber WE et al and the editorial by Wick MR (AJCP 2009;132:824). The articles are timely in indicating that pathology is lagging behind trends in web-based teaching and communications. However, quite a few web sites are appearing including this one that focus on such communications. We need more ideas on how web-based medium can improve pathology communication. Any ideas? <br/></span><br/>edited by Buddy on 12/11/2009<br/><em>edited by Buddy on 12/14/2009</em>]]></description>
<pubDate>Sun, 06 Dec 2009 13:08:15 GMT</pubDate>
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