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[RBC AGGLUTINATION]. Red blood cell agglutination indicates clumping of RBC’s due to cold agglutinins which are most commonly IgM antibodies. These antibodies cross-link red cells, which causes overlapping (arrow) and loss of central pallor. The agglutination leads to reduction in red cell count, elevation in MCH and MCV as measured by automated instruments.
[RBC AGGLUTINATION].The red cell agglutinates may be small or large and few to numerous depending on the amount of circulating agglutinins. Only a handful of conditions are known to cause production of agglutinins including typically Myoplasma infection (and a few other infections), B-cell lymphoproliferative disorders, and plasma cell dyscrasias. In the absence of any known cause for agglutinins the condition is known as idiopathic
[RBC AGGLUTINATION]. In some cases not only RBCs demonstrate agglutination (top arrowhead) but also lymphocytes (lower arrow) as in this case. This indicates the presence of circulating IgM antibodies against both RBCs and lymphocytes.
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