IMMUNOPEDIA is proud to announce collaboration with several vendors to provide its users with latest developments in the field of diagnostic immunohistochemistry. New additions to the growing list of immunohistochemical markers will be announced as soon as they are marketed and available for diagnostic use.

IMMUNOPEDIA is one of the most advanced and comprehensive web-based databases on the immunohistochemical and flow cytometric evaluation of human neoplasms. The database contains hundreds of quality references and is updated daily. Information about immunohistochemical markers and diseases can be accessed in more than one way that makes data mining exciting and informative. The data is compiled, reviewed, and entered by experts in the field ensuring inclusion of only peer-reviewed and quality citations. Users may suggest references to be included using Comment page.

Data collection and representation is at the core of IMMUNOPEDIA. We would like to share certain conventions with our users.

• Markers' clones are listed when reported explicitly or deduced implicitly from manfacturer's catalogue if only one clone existed for that marker.
• If a clone is not reported and more than one clone exist for a given marker, a designation "CNS (Clone not specified)" is used.
• Markers are listed alphabetically in a single list "All markers" and also grouped alphabetically for shorter browsing menues. A search box is also provided.
• Diseases are listed alphabetically in a single list "All tissues/Organs" and also grouped according to specific organ/tissue for shorter browsing menues.
• A disease's name has the following format: "Disease, subtype, Tissue/Organ (optional)." Names are listed exactly as reported or according to WHO schemes.
• If a disease occurs in more than one organ and a tissue/organ is not specified in the cited reference then the disease is listed under "Site unspecified."
• The entities marked as [non-neo] includes data for non-neoplastic tissue/cells and may include data on reactive tissue/cells.
• Each fragment of data, whether on a marker or a disease, is linked to its reference source. The link to the reference(s) lists all the cited references.
• / = Alternative names of markers are separated by a forward slash "/" such as TM / CD141, Melan-A / MART1, and CD117 / c-Kit.
• ( ) = Qualifier to a marker's name is shown in parenthesis "( )" including (c) for cytoplasmic, (n) for nuclear, (p) for phosphorylated, and (h) for human.
• { } = Correlation of immunohistochemical expression with molecular data for certain markers is shown in curly brackets "{ }" such as p16 {HPV DNA+} indicates IHC expression of p16 in all HPV DNA positive cases and p16 {HPV DNA-} indicates IHC expression of p16 in all HPV DNA negative cases.
• [ ] = Quantitative IHC expression of Her2 validated against FISH data is shown in sqaure "[ ]" brackets. This represents overall incidence and not correlation. Thus, Her2 [IHC 2+/FISH+] represents incidence of all cases which are positive for Her2 amplification by FISH and also show 2+ Her2 expression by IHC. Likewise, Her2 [IHC 3+/FISH-] represents incidence of all cases which are negative for Her2 amplification by FISH but show 3+ Her2 expression by IHC.

DISCOVER DIAGNOSTIC MARKERS - This module provides data on individual markers with reported incidence of positivity in various diseases. More than 300 markers included. The list of diseases can be sorted according to rate of positivity (default) or according to disease name. Markers are listed alphabetically in a single list "All markers" and also grouped alphabetically for shorter browsing menus. Marker's clone(s) used in the cited reference can be viewed by clicking "View clones."

EXPLORE REPORTED PATTERNS - This module provides data on individual diseases with expression pattern of various markers. You can view all the markers for a particular disease in the database or choose from 1 to 10 listed markers. The list of markers can be sorted according to rate of positivity (default) or according to marker name. Diseases are listed alphabetically in a single list "All tissues / Organs" and also grouped according to organs for shorter browsing menus. Marker's clone(s) used in the cited reference can be viewed by clicking "View clones."

COMPARE DISEASES' PROFILES - Upper panel: This module allows you to compare the marker expression pattern of one disease against any other. Only markers common to all members of the comparison are listed. You can perform comparison of two, three, or four diseases at a time. You must select at least two diseases. Expression level 75% or more is highlighted in blue, expression level 25% or less is highlighted in red, whereas expression level between 25% and 75% has no color coding.

COMPARE DISEASES' PROFILES - Lower panel: This module allows you to compare the marker expression pattern of two or more diseases using a selection of up to four markers. Only diseases common to all selected markers are listed. You can perform comparison of two, three, or four markers at a time. Expression level 75% or more is highlighted in blue, expression level 25% or less is highlighted in red, whereas expression level between 25% and 75% has no color coding.

ANALYZE EXPRESSION RESULTS - This module analyzes various expression patterns and yields a list of possible diagnoses based on selected markers and their incidence of positive expression reported in the literature. You can change the reported incidence of positivity to renew the search and obtain a new list. A "Positive" selection indicates an expression incidence that is >0%. A "Negative" selection indicate 0% expression incidence. However, you can also limit you search in other ranges for each marker.

CALCULATE MARKERS' STATISTICS - This module allows you to determine (1) sensitivity, (2) specificity, (3) positive predictive value,(4) negative predictive value, and (5) accuracy of a marker for a given disease against one or more other diseases. This involves assumption of a "True positive" expression of a marker in a disease and assumption of "True negative" expression of the marker in other diseases. You can select one to four diseases for assuming "True negative" expression or all diseases in the database.

pathpedia.com encourages its users to suggest high-quality peer-reviewed articles to be included in the database. However, we do not guarantee inclusion of suggested articles if we deem those articles to be of lesser quality, dubious methods, published in languages other than English, and articles with little clinical significance.