A Broad Survey of Cathepsin K Immunoreactivity in Human Neoplasms [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •discuss the difference in cathepsin K expression between carcinoma and mesenchymal lesions. •list neoplasms included in the morphological differential diagnosis of alveolar soft part sarcoma and discuss their cathepsin K expression. •outline the cellular role of cathepsin K and the transcription factors that affect its expression.  1 credit hour(s)   - Course Expires: December 31, 2015

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A Comparative Analysis of Molecular Genetic and Conventional Cytogenetic Detection of Diagnostically Important Translocations in More Than 400 Cases of Acute Leukemia, Highlighting the Frequency of False-Negative Conventional Cytogenetics [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: discuss the significance of recurrent genetic aberrations in acute leukemia and the methods that are available for their detection. compare the utility of conventional cytogenetics with that of multiplex reverse transcriptase–polymerase chain reaction in the classification of acute leukemia.  1 credit hour(s)   - Course Expires: April 30, 2014

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A Comparison of Equivocal Immunohistochemical Results With Anti-HER2/neu Antibodies A0485 and SP3 With Corresponding FISH Results in Routine Clinical Practice [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •define the breast cancer proportions of HER2/neu negative, equivocal, and positive results by immunohistochemistry recommended by American Society of Clinical Oncology/College of American Pathologists guidelines. •estimate the proportion of HER2/neu equivocal cases that are amplified by fluorescence in situ hybridization testing. •discuss the possible reasons why reported HER2/neu immunohistochemical results for a tumor sample might vary between laboratories and thus across studies. •list the possible reasons why a rabbit monoclonal antibody such as SP3 may reduce by 50% the number of equivocal results for HER2/neu immunohistochemistry compared with rabbit polyclonal A0485 antibody.  1 credit hour(s)   - Course Expires: April 30, 2014

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A Novel Thromboelastographic Score to Identify Overt Disseminated Intravascular Coagulation Resulting in a Hypocoagulable State [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: describe the underlying principle of thromboelastography as a test of hemostasis as well as some of its major limitations. list the individual components of the International Society on Thrombosis and Haemostasis scoring algorithm for overt disseminated intravascular coagulation. recognize the concept of a consolidated score derived from the various data obtained from the thromboelastogram to assess a hypocoagulable state holistically.  1 credit hour(s)   - Course Expires: May 31, 2013

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A Pain In The Neck: Fusobacterium Necrophorum Infection. Check Sample Microbiology 1106-CME/CMLE [Cme, Sam, Cmle]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators Upon completion of this activity, you will be able to: •describe Lemierre disease caused by Fusobacterium necrophorum. •discuss the epidemiology and the population at risk for F necrophorum disease. •explain the diagnostic procedures used to isolate and identify F necrophorum. •discuss the treatment and general outcome of F necrophorum infections.  1 credit hour(s)   - Course Expires: December 31, 2013

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A Primer on the HLA System. Check Sample Transfusion Medicine 1101-CME/CMLE [Cme, Sam, Cmle]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: identify the HLA structure, function, and methods. specify the importance of selection of HLA-compatible donors and screening for HLA antibodies before transplant. match patients with potential donors at the allele level. explain the complications of hematopoietic stem cell transplant. evaluate patients for donoe-specific antibodies. apply the 2011 HLA Nomenclature.  1 credit hour(s)   - Course Expires: December 31, 2013

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A Search for Reliable Molecular Markers of Prognosis in Prostate Cancer: A Study of 240 Cases AJAP1221 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •discuss the roles and limitations of the screening serum prostate-specific antigen test in the diagnosis and management of prostate cancer. •define the traditional clinical and pathologic indicators currently used by physicians to predict prostate cancer biological behavior and make management decisions. •discuss the limitations of traditional clinical and pathologic indicators of prognosis in prostate cancer. •define the number of patients with prostate cancer that were treated and the amount of money spent on that care to save 1 life in the United States in 2010, and how a reliable test of prognosis at the time of diagnosis can significantly reduce these figures.  1 credit hour(s)   - Course Expires: April 30, 2015

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A Synoptic Reporting System for Peripheral Blood Smear Interpretation [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •list several examples of synoptic reporting systems in both surgical pathology and hematopathology. •cite potential advantages and disadvantages of an Internet-based synoptic reporting system in peripheral blood smear reporting. •discuss potential improvements in resident education by implementation of a synoptic reporting system for peripheral blood smear interpretation and reporting. •list 2 examples in which morphologic findings on a peripheral blood smear can be combined with lab data and preexisting synoptic templates to generate a more comprehensive and useful final report. •describe several drawbacks inherent in the current model of resident education in peripheral blood smear interpretation and reporting.  1 credit hour(s)   - Course Expires: January 31, 2014

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A Systematic Review and Meta-Analysis of the Diagnostic Accuracy of Fine-Needle Aspiration Cytology for Parotid Gland Lesions [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •describe the role of quality assessment in a meta-analysis. •define the following terms: verification bias, review bias, misclassification bias, timing bias, and bias due to handling of indeterminate results. •discuss the current state of knowledge regarding the factors affecting the diagnostic performance of fine-needle aspiration cytology for the assessment of salivary gland lesions. •list the general categories of factors that lead to variation in diagnostic performance.  1 credit hour(s)   - Course Expires: May 31, 2014

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A Systematic Review and Meta-analysis of the Diagnostic Accuracy of Ultrasound-Guided Core Needle Biopsy for Salivary Gland Lesions [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •list the advantages and disadvantages of fine-needle aspiration cytology relative to core needle biopsy for salivary gland lesions. •understand the definitions of the major types of bias that occur in diagnostic accuracy studies: spectrum bias, verification bias, misclassification bias, and review bias. •describe the purpose of a quality assessment in a systematic review.  1 credit hour(s)   - Course Expires: August 31, 2014

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Achieving 95% Cross-Methodological Concordance in HER2 Testing: Causes and Implications of Discordant Cases. [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to:list key American Society of Clinical Oncology/College of American pathologists recommendations for HER2 test performance, interpretation, and validation.calculate assay concordance and how to perform validation of an HER2 testing methodology.list the primary causes of HER2 immunohistochemical (IHC) and fluorescence in situ hybridization discordance.identify the main reasons for interpreter error in HER2 IHC testing and apply this knowledge to improve HER2 IHC stain interpretation.  1 credit hour(s)   - Course Expires: June 30, 2013

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Acquired Activated Protein C Resistance Caused by Lupus Anticoagulants [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •compare and contrast the original, first-generation activated protein C resistance (APC-R) assay to the modified, second-generation APC-R assay. •describe the clinical features associated with lupus anticoagulants that help to define antiphospholipid antibody syndrome. •define the type of thrombosis, venous vs arterial, that might be expected with APC-R.  1 credit hour(s)   - Course Expires: July 31, 2014

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Acquired underproduction anemias [Cme]
Course sponsor: American Society of Hematology (ASH)
Erythrocyte production requires the presence of bone marrow stem cells, erythropoietin (EPO), elemental iron, vitamins, cytokines, and a suitable marrow microenvironment. Deficiency or unavailability of any of these key components may lead to the underproduction of erythrocytes and result in anemia. Normal erythropoiesis follows an ordered progression from the pluripotent colony-forming unit—granulocyte erythroid-monocyte macrophage (CFUGEMM), to the burst-forming units—erythroid (BFU-E), to colony-forming units—erythroid (CFU-E), to proerythro-blasts, to erythroblasts, and finally to mature erythrocytes (see Figure 12-1). Red blood cell (RBC) maturation is dependent on the presence of EPO, a 165—amino acid glycoprotein produced by the kidney.  2 credit hour(s)   - Course Expires: December 31, 2013

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Acral Myxoinflammatory Fibroblastic Sarcoma. Check Sample Surgical Pathology 2012 Exercise 9 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •describe the clinical features of acral myxoinflammatory fibroblastic sarcoma (AMIFS). •delineate the pathologic features of AMIFS. •highlight immunohistochemical and ultrastructural findings in AMIFS. •discuss the differential diagnosis of AMIFS. •establish the treatment and prognosis of AMIFS.  1 credit hour(s)   - Course Expires: December 31, 2014

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Acute lymphoblastic leukemia and lymphoblastic lymphoma [Cme]
Course sponsor: American Society of Hematology (ASH)
Acute lymphoblastic leukemia (ALL) is the most common leukemia in children (representing 23% of cancer diagnoses among children younger than 15 years of age) but accounts for only 20% of adult acute leukemia. The prognosis for both adult and especially childhood ALL has improved substantially in recent years with the use of risk-directed induction-consolidation-continuation (maintenance) regimens that include central nervous system (CNS) prophylaxis. In children, treatment now results in complete remission (CR) rates of 97% to 99% and in 5-year event-free survival rates of 75% to 86% (Pui et al, 2008, 2009).  2.5 credit hour(s)   - Course Expires: December 31, 2013

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Acute myeloid leukemia [Cme]
Course sponsor: American Society of Hematology (ASH)
Acute myeloid leukemia (AML) is a heterogeneous clonal stem cell malignancy in which immature hematopoietic cells proliferate and accumulate in bone marrow, peripheral blood, and other tissues. This results in inhibition of normal hematopoiesis, characterized by neutropenia, anemia, thrombocytopenia, and the clinical features of bone marrow failure. AML comprises 90% of all acute leukemias in adults, with approximately 13,000 new cases and 9000 deaths in the United States in 2009.  2.5 credit hour(s)   - Course Expires: December 31, 2013

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Acute Myeloid Leukemia With IDH1 or IDH2 Mutation: Frequency and Clinicopathologic Features. [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: describe the physiologic role of IDH1 and IDH2. describe the nature of IDH1 and IDH2 mutations. discuss the characteristics of acute myeloid leukemia with IDH1 and IDH2 mutations.  1 credit hour(s)   - Course Expires: November 30, 2013

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Acute Necrotizing Esophagitis. Check Sample Forensic Pathology 2012 Exercise 9 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •differentiate between common and rare causes of upper gastrointestinal hemorrhage. •describe the clinical manifestations, histologic characteristics, and suspected cause of necrotizing esophagitis. •distinguish between the characteristic findings in different stages of healing for necrotizing esophagitis. •recognize current theories explaining the mechanisms through which necrotizing esophagitis develops.  1 credit hour(s)   - Course Expires: December 31, 2014

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Adult-Onset Asthma and Periocular Xanthogranuloma. ASCP Case Reports Surgical Pathology 2013 Exercise 3 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •discuss the systemic effects and abnormalities associated with adult-onset asthma and periocular xanthogranuloma •correlate systemic symptoms with histologic features of periocular xanthomatous lesions to establish a diagnosis and predict clinical outcome. •differentiate non–Langerhans cell from Langerhans cell histiocytoses of the periocular region based on H&E-stained images and immunostain profile. •create a differential diagnosis for patients with refractory periocular edema. •plan treatment regimens for patients with adult-onset asthma and periocular xanthogranuloma.  2 credit hour(s)   - Course Expires: December 31, 2015

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ALDH, CA I, and CD2AP: Novel, Diagnostically Useful Immunohistochemical Markers to Identify Erythroid Precursors in Bone Marrow Biopsy Specimens AJHE1201 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Students, Pathologist Assistants Upon completion of this activity, you will be able to: •list a panel of immunohistochemical stains useful to identify erythroid precursors in bone marrow biopsy specimens. •describe the advantage of aldehyde dehydrogenase over glycophorin A and other erythroid markers. •list potential diagnostic pitfalls in using immunohistochemical stains to evaluate erythroid precursors.  1 credit hour(s)   - Course Expires: November 30, 2014

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Alleviation of IgM Monoclonal Protein Interference in Nephelometric Assays by Sample Treatment With Reducing Agent in a Chaotropic Salt Solution AJCC1202 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Students, Pathologist Assistants Upon completion of this activity, you will be able to: •describe proposed mechanisms for nephelometric interference observed in a subset of patients with IgM monoclonal gammopathy. •outline a method for alleviation of IgM nephelometric interference using a reducing agent.  1 credit hour(s)   - Course Expires: November 30, 2014

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An Accidental Manner of Death With Aortic Dissection. Check Sample Forensic Pathology 1107-CME [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •examine how cocaine and its breakdown products can predispose to an aortic dissection. •evaluate toxicology results to determine the manner of death in a case of aortic dissection. •evaluate a patient’s symptoms using the Stanford and the DeBakey dissection classification systems to predict the cause of an aortic dissection. •assess risk factors to evaluate the cause of an aortic dissection. •determine when toxicology testing should be considered in cases of aortic dissection.  1 credit hour(s)   - Course Expires: December 31, 2013

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An Assessment of the Usefulness of Immunohistochemical Stains in the Diagnosis of Hairy Cell Leukemia [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •identify the morphologic mimics of hairy cell leukemia (HCL) and the clinical importance of definitive diagnosis. •list 4 immunohistochemical stains that, as a panel, will assist in diagnosing HCL. •describe the limitations of current diagnostic techniques when HCL is considered.  1 credit hour(s)   - Course Expires: July 31, 2014

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An Examination of the Usefulness of Repeat Testing Practices in a Large Hospital Clinical Chemistry Laboratory AJCC1201 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Students, Pathologist Assistants Upon completion of this activity, you will be able to: •list the "triggers" that are commonly used to institute automated or manual repeat laboratory testing such as critical values, delta checks, and values outside of the analytic measurement range (AMR). •examine repeat testing practices at their own institution to determine whether repeating tests within the AMR results in the identification of significant numbers of analytical errors. •predict what types of historical repeat triggers may no longer be necessary in a contemporary automated laboratory setting.  1 credit hour(s)   - Course Expires: November 30, 2014

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An Overview of Current Bariatric Procedures and Review of Complications. Check Sample Forensic Pathology 2012 Exercise 4 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •define morbid obesity. •determine the appropriate criteria for bariatric surgery. •describe the postsurgical anatomical changes resulting from different bariatric procedures. •explain the differences among the Roux-en-Y gastric bypass, adjustable gastric banding, laparoscopic sleeve gastrectomy, and biliopancreatic diversion with duodenal switch bariatric surgical procedures. •discuss the physiologic mechanisms responsible for weight loss after bariatric surgery. •identify and predict common complications associated with bariatric surgery.  1 credit hour(s)   - Course Expires: December 31, 2014

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Anatomic Pathology Electronic Case Series (APECS) [Cme]
Course sponsor: United States & Canadian Academy of Pathology (USCAP)
The Anatomic Pathology Electronic Case Series (APECS) Program is an interactive, online continuing medical education activity which is sponsored by the United States and Canadian Academy of Pathology (USCAP). It is intended for practicing pathologists and pathologists in training. Content is provided by the membership of the Academy, and individuals interested in becoming an author are encouraged to submit proposals.  4-8 credit hour(s)  

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Angioedema of the Tongue: A Rare Cause of Asphyxia in a Homicide. Check Sample Forensic Pathology 1101-CME [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: describe the pathophysiology of angioedema. discuss circumstances in which angioedema can cause asphyxia. evaluate a differential diagnosis of angioedema in living patients. evaluate angioedema as a possible cause of death at autopsy. determine the manner of death in an investigation in which angioedema may play a role.  1 credit hour(s)   - Course Expires: December 31, 2013

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Aortic Aneurysm, Graft Dehiscence, and Perforation With Remote History of Repair of Coarctation of the Aorta. Check Sample Forensic Pathology 1102-CME [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: investigate for bicuspid aortic valve in a patient with coarctation of the aorta (CoA). identify the rate of aneurysm formation in patients with previous CoA repair. discuss the most common causes of aortobronchopulmonary fistula. recognize the pathognomonic feature of an aortobronchopulmonary fistula in a patient with a history of thoracic aorta surgery. recognize the symptom triad indicative of a mycotic aneurysm in a patient with CoA. implement a radiologic screening program and schedule for a patient with a history of CoA repair with a patch aortoplasty to assess for aneurysm formation.  1 credit hour(s)   - Course Expires: December 31, 2013

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Appendiceal Adenocarcinoma. Check Sample Surgical Pathology I 1101-CME [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •formulate a differential diagnosis for an appendiceal mass. •describe the histopathologic features of common appendiceal tumors. •identify features of staging and prognostic importance in the evaluation of appendiceal tumors. •apply genetic testing for Lynch syndrome in colorectal carcinoma according to Bethesda guidelines.  1 credit hour(s)   - Course Expires: December 31, 2013

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Archives Applied - Acute Erythroid Leukemia [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This self assessment module (SAM) is based on an article about acute erythroid leukemia that appeared in the September 2010 issue of "Archives of Pathology & Laboratory Medicine." It was developed by an expert in the field, Zhuang Zuo, MD, PhD. This SAM is designed for pathologists to heighten their awareness of acute erythroid leukemia (AEL). Pathologist expertise is essential to recognizing the clinical presentation, morphologic features, immunophenotype, and cytogenetic and molecular data associated with AEL. As a result of participating in this SAM eligible activity, you will be able to: 1) identify the current criteria for the diagnosis of AEL; 2) identify the clinical features of AEL; 3) identify typical morphologic and cytochemical findings of AEL; 4) identify Immunophenotypic findings of AEL; and 5) distinguish the features that indicate a diagnosis of AEL versus other types of AML.  1 credit hour(s)   - Course Expires: January 30, 2014

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Archives Applied - Barrett Esophagus and Related Dysplasia [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This SAM developed by John R. Godblum, MD is based on an article that appeared in the October 2010 issue of "Archives of Pathology and Laboratory Medicine". It is designed for pathologists to heighten their awareness of controversies in the diagnosis of Barrett esophagus and Barrett-related dysplasia. As a result of participating in this activity you will be able to: 1) identify the criteria for a diagnosis of Barrett esophagus (BE); 2) identify the criteria for low-grade versus high-grade dysplasia in an esophageal biopsy specimen; 3) distinguish between regenerative changes and Barrett-related dysplasia in an esophageal biopsy; 4) describe the challenges in distinguishing high-grade dysplasia (HGD) from intramucosal adenocarcinoma (IMC); and 5) describe the histologic features that are highly predictive of finding an invasive adenocarcinoma in the esophagectomy specimen.  1 credit hour(s)   - Course Expires: October 23, 2014

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Archives Applied - Lessons from Laboratory Drug Testing Surveys [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This SAM developed by Stacy E. F. Melanson, MD, PhD, FCAP is based on an article that appeared in the May 2010 "Archives of Pathology & Laboratory Medicine." It is designed for pathologists to heighten their awareness of laboratory drug testing. As a result of participating in this activity, you will be able to: 1) describe strategies for identifying the most appropriate assays for a specific laboratory or patient population. Identify the drugs or classes of drugs and the associated immunoassays for which false-negative results are commonly seen; 2) recognize that certain drugs can trigger positive results below the assay cutoff; 3) identify the drugs which may trigger false-positive results by a specific immunoassay; and 4) describe the limitations of benzodiazepine immunoassay urine drug screens.  1 credit hour(s)   - Course Expires: January 22, 2015

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Archives Applied - Lobular Carcinoma in Situ Variants (LCIS) in Breast Cores [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This SAM developed by Megan E. Sullivan, MD, FCAP is based on an article that appeared in the July 2010 issue of "Archives of Pathology and Laboratory Medicine". Pathologist expertise is essential to assist clinicians with differentiating ductal carcinoma in situ (DCIS) from LCIS. This SAM is designed for pathologists to heighten their awareness of lobular carcinoma in situ (LCIS) variants in breast cores. As a result of participating in this SAM eligible activity, you will be able to: 1) identify the histologic features that indicate a lesion may represent either lobular carcinoma in situ (LCIS) with necrosis or pleomorphic LCIS; 2) identify the pathologic features associated with misclassification of LCIS variants as ductal carcinoma in situ (DCIS); 3) identify the risk of upgrade at the time of surgical excision of LCIS variants diagnosed on needle core biopsy; and 4) describe the possible treatment implications for patients diagnosed with a LCIS variant versus a "solid" DCIS.  1 credit hour(s)   - Course Expires: October 09, 2014

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Archives Applied - Microparticles and Leukofiltration [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This SAM developed by Kenneth E. Nollet, MD, PhD is based on an article that appeared in the May 2010 issue of "Archives of Pathology & Laboratory Medicine" about prestorage leukofiltration of whole blood. As a result of participating in this activity, you should be able to: Characterize microparticles in terms of their origin, significance, and how they are detected. Describe the effects of leukocyte filtration beyond the removal of leukocytes from blood. Quantify the extent to which PDMP-gated events and PLT-gated events may increase in whole blood during cold storage. Describe the potential benefits to patients of reduced PDMP levels in stored blood. Describe the most plausible relationship between PLT-gated events and PDMP-gated events in unfiltered whole blood.  1 credit hour(s)   - Course Expires: November 13, 2014

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Archives Applied - Placental Membrane Hypoxic Lesions [Cme, Sam]
Course sponsor: College of American Pathologist (CAP)
This SAM is based on an article by Jerzy Stanek, MD, PhD, FCAP that appeared in the July 2010 issue of "Archives of Pathology & Laboratory Medicine" about diagnosing placental membrane hypoxic lesions. As a result of participating in this SAM eligible activity, you will be able to: 1) identify microscopic chorionic pseudocysts in placental membranes; 2) identify histological patterns of chronic hypoxic placental injury; 3) identify features of membrane laminar necrosis versus membrane fibrin deposition; 4) distinguish typical clinical associations of laminar necrosis (LN) versus microscopic chorionic pseudocysts (MCP); and 5) describe the significance of recognizing preuterine, uterine, and postuterine placental hypoxia clinically and histologically.  1 credit hour(s)   - Course Expires: August 22, 2014

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Are Routine Ancillary Stains Required to Diagnose Helicobacter Infection in Gastric Biopsy Specimens? An Institutional Quality Assurance Review AJAP1208 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •describe the salient histological features of Helicobacter pylori gastritis. •define and utilize an evidence-based strategy for the diagnosis of H pylori gastritis using routine H&E-stained sections and ancillary studies, particularly immunohistochemistry.  1 credit hour(s)   - Course Expires: December 31, 2014

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Arginase-1, HepPar-1, and Glypican-3 Are the Most Effective Panel of Markers in Distinguishing Hepatocellular Carcinoma From Metastatic Tumor on Fine-Needle Aspiration Specimens AJAP1239 [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants Upon completion of this activity, you will be able to: •apply arginase-1 (Arg-1) antibody when working up a tumor of unknown origin in either surgical or fine-needle aspiration specimens. •define effective immunostaining panels to distinguish among benign hepatocytes, primary hepatocellular carcinoma, and metastatic carcinoma involving the liver.  1 credit hour(s)   - Course Expires: June 30, 2015

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Array Comparative Genomic Hybridization of Peripheral Blood Granulocytes of Patients With Myelodysplastic Syndrome Detects Karyotypic Abnormalities [Cme]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: list 2 advantages of array comparative genomic hybridization (aCGH) over conventional cytogenetics. describe the role of aCGH on circulating granulocytes of patients with myelodysplastic syndrome.  1 credit hour(s)   - Course Expires: May 31, 2013

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Array Comparative Genomic Hybridization of Peripheral Blood Granulocytes of Patients With Myelodysplastic Syndrome Detects Karyotypic Abnormalities [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Upon completion of this activity, you will be able to: list 2 advantages of array comparative genomic hybridization (aCGH) over conventional cytogenetics. describe the role of aCGH on circulating granulocytes of patients with myelodysplastic syndrome.  1 credit hour(s)   - Course Expires: May 31, 2013

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Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy: A Cause of Sudden Death. Check Sample Forensic Pathology 1105-CME [Cme, Sam]
Course sponsor: American Society for Clinical Pathology (ASCP)
Intended Audience: Pathologists, Residents, Med Students, and Pathologist Assistants Upon completion of this activity, you will be able to: •discuss the key clinical features of arrhythmogenic right ventricular dysplasia/ cardiomyopathy (ARVD/C). •explain the characteristic histopathology of ARVD/C. •implement screening procedures for patients and their family members. •describe treatment options for patients with ARVD/C and their family members. •distinguish Naxos disease from Carvajal syndrome.  1 credit hour(s)   - Course Expires: December 31, 2013

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