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Rhabdoid tumor of the kidney
Rhabdoid tumor of the kidney


Can we have a reliable urine test for prostate cancer?
by: Craig G. Fisher, M.D, PhD

Estrogens are known to be risk factors in the development/progression of prostate cancer. Yang et al, in a case-controlled study, found one metabolite catechol estrogen quinones using HPLC/TMS to be elevated in a group of 14 patients with prostate cancer.
[Prostate. 2009 Jan 1;69(1):41-8.]


Risk for chronic myeloproliferative disorders may be an inherited one?
by: Editorial Board

Chronic myeloproliferative disorders polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are clonal proliferative hematopoietic disorders that may harbor JAK2 V617F mutation. In three separate recent reports published in Nature Genetics a specific constitutional haplotype is identified suggesting genetic susceptibility to these disorders.
[Nature Genetics, 15 March 2009]


Vitamin B3 may boost your neutrophil count?
by: Yuan Xie, M.D, PhD

J Skokowa et al identified nicotinamide phosphoribosyltransferase (NAMPT) as an essential enzyme promoting granulocyte colony-stimulating factor (G-CSF)-mediated granulopoiesis in healthy individuals and in patients with severe congenital neutropenia.
[Nature Medicine 15, 151-158 (1 February 2009)]


Development of a new quantitative immunoassay for factor VIII antibodies.
by: M. Hanif Pathan, M.D

The quantitation of factor VIII antibodies is currently performed using Nijmegen method which is a modification of the Bethesda assay. However, the use of this new quantitative fluorescence-based immunoassay, developed by Krudysz-Amblo et al also detected antibodies not quantitated by Nijmegen method.
[Blood, 12 March 2009, Vol. 113; pp 2587-2]


Rudolf LK Virchow
Rudolf LK Virchow, aptly known as the father of pathology, owes our appreciation and recognition of the numerous seminal contributions he made to the field of medicine and specifically to the discipline of pathology.
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